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Adipogen/antiParaoxonase 1, mAb (17A12)/YIFLFMA0099/100 µl

时间: 1628445603 来源: 苏州蚂蚁淘 阅读 (14)
MoreInformation
ProductDetails
SynonymsPON;PON1;K-45;PON1;EC=3.1.8.1;EC=3.1.1.2;EC=3.1.1.81;A-Esterase1;AromaticEsterase1;SerumAryldialkylphosphatase1;SerumParaoxonase/Arylesterase1
ProductTypeMonoclonalAntibody
Properties
Clone17A12
IsotypeMouseIgG1κ
Immunogen/AntigenRecombinanthumanHis-PON1proteinpurifiedE.coli.
ApplicationWesternBlot(1:500)
CrossreactivityHuman
Mouse
Rat
PurityDetailAmmoniumsulfateprecipitation.
FormulationLiquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol.
OtherProductDataClickhereforOriginalManufacturerProductDatasheet
Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.
DeclarationManufacturedbyAbFrontier
ShippingandHandling
ShippingBLUEICE
ShortTermStorage+4°C
LongTermStorage-20°C
Use/StabilityStableforatleast1yearafterreceiptwhenstoredat-20°C.
Documents
MSDSNo
ProductSpecificationSheet
DatasheetDownloadPDF
Theparaoxonase(PON)gene-familyinhumanshasthreemembers,PON1,PON2,andPON3,alignednexttoeachotheronthelongarmofchromosome7q21.3-22.1.PON1oftheseissynthesizedprimarilyintheliverandaportionissecretedintotheplasma,whereitisassociatedwithhighdensitylipoproteins(HDL).AndIthydrolyzestheactivemetabolitesofseveralotherorganophosphorusinsecticides(e.g.,chlorpyrifosoxon,diazoxon),aswellasnerveagentssuchassarin,somanandVX(lethalnerveagent).ThePON1polymorphismmayberesponsibleforneurodegenerationandconsideredtobeanindependentriskfactorforParkinson’sdisease.Hydrolyzesthetoxicmetabolitesofavarietyoforganophosphorusinsecticides.Capableofhydrolyzingabroadspectrumoforganophosphatesubstratesandanumberofaromaticcarboxylicacidesters.Maymediateanenzymaticprotectionoflowdensitylipoproteinsagainstoxidativemodificationandtheconsequentseriesofeventsleadingtoatheromaformation.
ProductReferences
1)AkhmedovaSN,etal.(2001)JNeurolSci184(2):179-82.(General)
2)KondoI,etal.(1998)BrainRes806(2):271-3.(General)

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